Doulci Activator Software
BYE BYE ITUNES
Doulci Team, today we present our software to bypass iCloud. Doulci Activator is a software which allows to bypass iCloud without the need to use Itunes anymore.
Tuesday, June 24, 2014
Sunday, June 22, 2014
Geohot “makes it ra1n” on Android with a rooting tool for the Samsung Galaxy S5
Geohot—a name that’s virtually synonymous with iPhone jailbreaking—has taken up quite a few different ventures since departing from the jailbreak scene.
How to record the screen on Mac for free
I was recently streaming the Stanley Cup Finals and waiting for a new Apple commercial to air during the first period.
Wednesday, June 18, 2014
How To Officially Unlock iPhone 3GS/4/4S/5/5S/5C Locked on AT&T USA
How To Officially Unlock iPhone 3GS/4/4S/5/5S/5C Locked on AT&T USA – After receiving many emails and messages we have take the decision to create this post about the Official Factory Unlocking iPhone service, Officialunlocked.com.
Tuesday, June 17, 2014
Apple Icloud Activation Bypass Alternative to Doulci
GadgetWide iCloud Server
We have had reports of devices failing to activate. To counteract this we are offering a temporary IP based solution which is still a work in progress.
Monday, June 16, 2014
A 100-year-old drug corrects autistic social behaviors in lab tests
Old drugs can sometimes yield surprising results. A well-known diabetes pill called Metformin, for instance, is now being used to treat certain cancers. And Thalidomide, a drug used as a sedative in the ’50s, is now used to treat leprosy and bone marrow cancer. But a new study published today in Translational Psychiatry might beat these examples, as it reveals that suramin, a drug that was developed in 1916 to treat African sleeping sickness, can restore normal social behaviors in adult mouse models of autism. These results won't lead to new autism therapies right away — suramin has not been tested on humans with autism, and it's actually toxic if dispensed for longer than a few months — they do hint at the new directions that researchers might explore.
THE MICE BECAME MORE SOCIAL AFTER A SINGLE DOSE
In the study, researchers administered a dose of suramin to 25 male mice, whereas another 25 males received a saline injection instead. All mice were "maternal immune activation mouse models," meaning animals that exhibit autism-like behaviors following a virus infection in their mothers during pregnancy. This single dose, the researchers report, corrected the social behaviors seen in autism spectrum disorder. The mice, for instance, spent more time interacting with both mice and objects they had never interacted with before, compared to those injected with a saline solution. The benefits lasted for five weeks after the drug was washed out of their system.
The scientists think suramin acts by binding to, and inhibiting, 19 different receptors — called "purinergic" receptors — that are expressed on every cell type in the body. This binding action prevents ATP, our body's energetic currency unit, from binding to these specific receptors, which then helps turn off a cellular response known as the "cell danger response."
THE CELL DANGER RESPONSE CAN CHANGE THE TRAJECTORY OF NEURODEVELOPMENT
"The cell danger response is an evolutionarily conserved set of about 30 metabolic changes that help protect cells from threat," explained Robert Naviaux, a geneticist at the University of California San Diego and lead author of the study, in an email to The Verge. These metabolic changes can be beneficial, because they allow the re-allocation of energetic resources in times of stress, like when the body encounters viruses, pollutants, or even certain drugs. But "when significant exposures happen during pregnancy or in early childhood," Naviaux said, "the trajectory of neurodevelopment can be changed." Moreover, "cells retain a metabolic memory of these significant exposures according to the severity of the stress and the developmental timing of the exposure."
So, if the change in resource allocation is severe enough, it may also alter normal cellular functions that are required for healthy neurodevelopment. And suramin's binding action seems to reverse this change in function by allowing cells to return to their normal metabolism, Naviaux said — "and their normal jobs."
SURAMIN IS TOXIC IN THE LONG-RUN
Unfortunately, suramin can't be administered for longer than a few months because of long-term toxicity. Naviaux thinks people shouldn't focus on that aspect of the study, however, because scientist may one day find less damaging drugs that have similar effects. These therapies could be given "only once or intermittently," he says, to unblock metabolism and restore more normal social behaviors.
"This really takes a novel approach to understanding what's going on in autism," says Richard Frye, director of autism research at the University of Arkansas who did not participate in the study. "I think the argument that, when a cell senses danger, it changes its metabolism to protect itself makes a lot of sense — and it makes a lot of sense with what we see in autism."
"IT MAKES A LOT OF SENSE WITH WHAT WE SEE IN AUTISM."
But other researchers are less enthusiastic. "[The findings] are valuable, but the main problem is that they rely on a model of immune infection, not a genuine model of autism," said Yehezkel Ben-Ari, an autism researcher at the Mediterranean Institute of Neurobiology who was not involved in the study, in an email to The Verge. "They should have tested one of the classical models of autism," he said — meaning genetic models of autism — to see whether suramin indeed corrects autistic behaviors.
Naviaux has heard such criticisms before, and argues that the model is appropriate given that serious viral infections and fevers during human pregnancy can increase the risk of autism and other neurodevelopmental disorders in children. In addition, he said, the mouse model "actually produces more severe symptoms" than many of the conventional autism animal models. "No animal model is a perfect match for complex human diseases like autism or schizophrenia," Naviaux said, but this is "one of the best."
There are other possible limitations to this work. For example, this mouse model doesn't reproduce all behaviors linked to autism, such as repetitive behaviors. The study also involved a small number of mice, and the researchers only tested suramin on males.
"GENES INTERACT WITH ENVIRONMENTAL FACTORS."
It should also be noted that Naviaux's explanation for behavioral symptoms seen in people with autism spectrum disorder doesn't contradict current notions regarding its genetics. "It is very clear that genes interact with environmental factors to cause autism," Naviaux said. But "even in the rare cases of single genes that can increase the risk of autism spectrum disorders, no single-gene disorder produces [autism] in 100 percent of the children who have the gene."
The idea that autism might be the result of abnormal cell communication is still fairly new. But Naviaux thinks exploring the cell danger response theory is important. "According to the theory, abnormal cell metabolism can result from genes, environment, or both," he said. So, the key to treatment may lie in finding the way to restore normal cell metabolism, and more normal development as a result. "Some things that we thought were a permanent feature of the mouse models, are actually treatable with the right metabolic intervention," Naviaux said, which means that "despite the permanent loss of certain brain cell connections in the mouse models of autism ... social and exploratory behaviors can be improved with the right treatment."
Cosmic radiation will finally get us inside the Fukushima reactors
Every second of every day, muons — tiny, electron-like particles — are raining down on the planet.
Apple is providing T-Mobile with free iPhones for 'Test Drive' program
Just who is providing all the iPhones that will be offered to potential T-Mobile customers as part of a new program that lets people test drive the carrier's network for a week?
iPad Air vs other tablet devices
Earlier this month tech giant Apple unveiled the new iPad Air tablet device. With an improved design, faster processor and powerful camera features, the Air is set to perform well on the consumer market. Boasting a 9.7-inch screen and a 2,048 x 1,536 resolution, all in a sleek looking frame that weighs just one pound, the newest Apple release is a significant jump forward from its predecessor.
iPhone 6 supposedly on its final build leaked
And we are approaching the month where the new breed of iPhone will be officially unveiled and if the claim of a new tipster from the Chinese supply chain, these leaked photos shown featured the iPhone 6 on its final build.
Out now: iOS 8 Beta 2, Yosemite Developer Preview 2, new Xcode and Apple TV software
Two weeks after releasing the first beta of iOS 8, Apple today seeded it developers with the second beta of both iOS 8 and OS X Yosemite.
T-Mobile's 'Music Freedom' is a great feature — and a huge problem
Net neutrality has seen headier days, and to be honest, it never stood a chance in the wireless industry — but T-Mobile just drove the point home at its "Uncarrier 6.0" announcement in Seattle this evening.
Download iOS 8 Beta 1 for iPhone, iPod Touch and iPad
Download iOS 8 Beta 1 for iPhone, iPod Touch and iPad – After waiting for months, Apple has finally introduced the iOS 8. Well, if you are a developer, you will be lucky enough to get your hands on the most advanced mobile OS iOS 8 from today. Yes, Apple has rolled out the iOS 8 beta 1 for developers.
Download iOS 8 Beta 1 for iPhone, iPod Touch and iPad
Siri gets Improvements with new features in iOS 8
Siri gets Improvements with new features in iOS 8 – Well, we saw a handful of new features in iOS 8, but thing is that Apple hasn’t left the revolutionary digital assistant out in the cold. The Cupertino Company has introduced some new features in the Siri as well. Although they aren’t quite game changing, but still they aremuch needed features for every Siri user.
Siri gets Improvements with new features in iOS 8
Hey, Siri:
Now, you will not have to press and hold the Home button to wait Siri pop out for you. Simply plug iPhone charger and say “Hey, Sir”, it will automatically open the Siri. This new feature is actually a rip-off Android “Google Now”, “OK, Google”. But it will be very helpful especially when you are driving car.
Shazam Song Recognition:
Many reports and rumors already told that Apple will bring Shazam recognition feature in Siri. Well, here it is! What will it actually do? Whenever a song is playing on an external source, Siri will be able to recognize that song and will redirect you to iTunes to tell further details about Artists, Album and Title. Users will also be able to buy that song via iTunes.
Purchase iTunes Content:
Using Siri, you will also be able to purchase iTunes content such as by using the Shazam Song recognition feature.
Streaming Voice Recognition:
Alongside of Shazam like feature, Siri will also be able to recognize the “Streaming Voices”.
22 new dictation languages:
Dictation language is my most favorite feature, whenever, I don’t feel like writing. I can talk and Siri will automatically write. The good news is that this feature will now introduced in 22 different languages.
Which one is your most favorite Siri Feature from recent update? Let us know in the comments section below.
Subscribe to:
Posts
(
Atom
)
Posts
